The ICMR-DHR outreach program, conceptualized under the guidance of the DG ICMR, is actively engaging with ethics committees in rural India to gain a comprehensive understanding of the challenges they encounter in their daily operations. This initiative is focused on identifying gaps in existing guidelines and rules, particularly in terms of their completeness and adaptability at the functional level of ethics committees. As a key enabler of research in the country, the ICMR-DHR outreach program is positioned to provide future direction for guideline development and offer a deeper understanding of other ICMR and DHR initiatives.